Post-doctoral position (3 years)

CNRS, Université Pierre et Marie Curie, UMR 7622, Laboratoire de Biologie du Développement
9, Quai Saint-Bernard, Bât. C, 6ème étage, Case 24, 75252 PARIS Cedex 05
http://bio-dev.snv.jussieu.fr/
Post-doctoral position (3 years)

Use of stem cells to generate tendons
A 3 year post-doc position is available from March 2009 in Delphine DUPREZ’s
team, in Paris.

Tendon and ligament injuries are common clinical problems during aging or following
accidents. No treatment currently exists to restore injured or defective tendon to its normal
condition. The ultimate aim of this project is to build an in vitro tendon (or ligament) for
transplantation into patients with defective tendons. We shall to use knowledge that we have
acquired concerning tendon formation during embryonic development in order to establish an
in vitro system able to build a tendinous structure.
The project will involve cell culture of adult mesenchymal stem cells (from mouse,
rat) and transfection experiments of these mesenchymal stem cells with the appropriate
factors in order to trigger differentiation towards a tendon phenotype. The project will also
require in vivo manipulation in the chick embryos and the use of mouse mutant lines.
A background in mesenchymal stem cells and/or cell culture will be an advantage.
Applicants may be of any nationality and should have obtained the equivalent of a
PhD. Salary will be at least 2500 Euros per month (depending upon experience). Applications
including a CV, a description of previous research experience, and 2 or 3 names of referees
should be sent to Delphine DUPREZ by mail Delphine.duprez@upmc.fr